Single caudate neurons encode temporally discounted value for formulating motivation for action | bioRxiv

Single caudate neurons encode temporally discounted value for formulating motivation for action | bioRxiv

Temporal discounting captures both choice preferences and motivation for delayed rewards. While temporally discounted value for choice is represented in brain areas including the dorsolateral prefrontal cortex (DLPFC) and the striatum, the neural process of motivation for delayed rewards remains unidentified. Here we show that neuronal activity of the dorsal part of the primate caudate head (dCDh) — a striatal region receiving projection from the DLPFC — signals temporally discounted value essential for computing motivation for delayed rewards. Macaque monkeys performed an instrumental task, in which a visual cue indicated the forthcoming size and delay duration before reward. Single dCDh neurons represented the temporally discounted value without reflecting changes in the animal’s physiological state. Bilateral pharmacological or chemogenetic inactivation of dCDh specifically distorted a normal motivational performance based on the integration of reward size and delay. These results s

3 mentions: @biorxivpreprint@biorxiv_neursci
Date: 2020/05/23 02:21

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