Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study | bioRxiv

Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study | bioRxiv

Diffusion tractography MRI can infer changes in network connectivity in patients with traumatic brain injury (TBI), but pathological substrates of disconnected tracts have not been well-defined due to a lack of high-resolution imaging with histopathological validation. We developed an ex vivo MRI protocol to analyze tract terminations at 750 micron resolution, followed by histopathologic evaluation of white matter pathology, and applied these methods to a 60-year-old man who died 26 days after TBI. Analysis of 74 cerebral hemispheric white matter regions revealed a heterogeneous distribution of tract disruptions. Associated histopathology identified variable white matter injury with patchy deposition of amyloid precursor protein and loss of neurofilament-positive axonal processes, myelin dissolution, astrogliosis, microgliosis, and perivascular hemosiderin-laden macrophages. Multiple linear regression revealed that tract disruption strongly correlated with neurofilament loss. Ex vivo d

4 mentions: @AndrewZalesky@ComaRecoveryLab@biorxiv_neursci
Date: 2020/07/22 20:21

Referring Tweets

@AndrewZalesky Linking tractography streamlines and histopathology (n=1) Streamlines terminating in white matter interpreted as evidence of axonal injury and significantly associate with neurofilament loss , but not other histological markers t.co/CaiDCR8UNM t.co/CQ5vWyHMAq
@ComaRecoveryLab MRI tractography maps brain network disconnections in patients with #TBI, but its pathological correlates are unknown. We found that tract disruptions reflect axonal injury, providing a pathological basis for MRI tractography as a brain mapping tool. t.co/8B4ktDPpJx [1/6]

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